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TitleChemo-Immunotherapeutic Anti-Malarials Targeting Isoprenoid Biosynthesis.
Journal, issue, pagesACS MED. CHEM. LETT., Vol. 4, Page 423-427, Year 2013
Publish dateJul 24, 2012 (structure data deposition date)
AuthorsZhang, Y. / Zhu, W. / Liu, Y.L. / Wang, H. / Wang, K. / Li, K. / No, J.H. / Ayong, L. / Gulati, A. / Pang, R. ...Zhang, Y. / Zhu, W. / Liu, Y.L. / Wang, H. / Wang, K. / Li, K. / No, J.H. / Ayong, L. / Gulati, A. / Pang, R. / Freitas-Junior, L. / Morita, C.T. / Old-Field, E.
External linksACS MED. CHEM. LETT. / PubMed:23610597
MethodsX-ray diffraction
Resolution2.39 Å
Structure data

PDB-4ga3:
Crystal Structure of Human Farnesyl Diphosphate Synthase in Complex with BPH-1260
Method: X-RAY DIFFRACTION / Resolution: 2.39 Å

Chemicals

ChemComp-4GA:
1-butyl-3-(2-hydroxy-2,2-diphosphonoethyl)-1H-imidazol-3-ium

ChemComp-MG:
Unknown entry

ChemComp-PO4:
PHOSPHATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / all alpha helices / cytosol

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