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-Structure paper
Title | Design, synthesis, and pharmacological evaluation of monocyclic pyrimidinones as novel inhibitors of PDE5. |
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Journal, issue, pages | J. Med. Chem., Vol. 55, Page 10540-10550, Year 2012 |
Publish date | Jul 13, 2012 (structure data deposition date) |
![]() | Wang, G. / Liu, Z. / Chen, T.T. / Wang, Z. / Yang, H. / Zheng, M. / Ren, J. / Tian, G. / Yang, X. / Li, L. ...Wang, G. / Liu, Z. / Chen, T.T. / Wang, Z. / Yang, H. / Zheng, M. / Ren, J. / Tian, G. / Yang, X. / Li, L. / Li, J. / Suo, J. / Zhang, R. / Jiang, X. / Terrett, N.K. / Shen, J. / Xu, Y.C. / Jiang, H. |
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Methods | X-ray diffraction |
Resolution | 2.28 - 2.4 Å |
Structure data | ![]() PDB-4g2w: ![]() PDB-4g2y: |
Chemicals | ![]() ChemComp-NI0: ![]() ChemComp-MG: ![]() ChemComp-PEG: ![]() ChemComp-ZN: ![]() ChemComp-HOH: ![]() ChemComp-NI5: |
Source |
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![]() | HYDROLASE/HYDROLASE INHIBITOR / phosphodiesterase / HYDROLASE-HYDROLASE INHIBITOR complex |