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-Structure paper
Title | Preparation and optimization of new 4-(morpholin-4-yl)-(6-oxo-1,6-dihydropyrimidin-2-yl)amide derivatives as PI3K beta inhibitors |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 22, Page 6381-6384, Year 2012 |
Publish date | Jul 10, 2012 (structure data deposition date) |
Authors | Certal, V. / Halley, F. / Virone-Oddos, A. / Thompson, F. / Filoche-Romme, B. / El-Ahmad, Y. / Carry, J.C. / Delorme, C. / Karlsson, A. / Abecassis, P.Y. ...Certal, V. / Halley, F. / Virone-Oddos, A. / Thompson, F. / Filoche-Romme, B. / El-Ahmad, Y. / Carry, J.C. / Delorme, C. / Karlsson, A. / Abecassis, P.Y. / Vincent, L. / Bonnevaux, H. / Nicolas, J.P. / Morales, R. / Michot, N. / Vade, I. / Louboutin, A. / Perron, S. / Doerflinger, G. / Tric, B. / Monget, S. / Lengauer, C. / Schio, L. |
External links | Bioorg. Med. Chem. Lett. / PubMed:22981333 |
Methods | X-ray diffraction |
Resolution | 3.4 Å |
Structure data | PDB-4g11: |
Chemicals | ChemComp-0W7: |
Source |
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Keywords | Transferase/Transferase Inhibitor / PHOSPHOINOSITIDE 3-KINASE GAMMA / SECONDARY MESSENGER GENERATION / Transferase-Transferase Inhibitor complex |