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Structure paper

TitleExcision of 5-hydroxymethyluracil and 5-carboxylcytosine by the thymine DNA glycosylase domain: its structural basis and implications for active DNA demethylation.
Journal, issue, pagesNucleic Acids Res., Vol. 40, Page 10203-10214, Year 2012
Publish dateJun 19, 2012 (structure data deposition date)
AuthorsHashimoto, H. / Hong, S. / Bhagwat, A.S. / Zhang, X. / Cheng, X.
External linksNucleic Acids Res. / PubMed:22962365
MethodsX-ray diffraction
Resolution2.493 Å
Structure data

PDB-4fnc:
Human TDG in a post-reactive complex with 5-hydroxymethyluracil (5hmU)
Method: X-RAY DIFFRACTION / Resolution: 2.493 Å

Chemicals

ChemComp-HMU:
5-HYDROXYMETHYL URACIL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE/DNA / base excision repair / HYDROLASE-DNA complex

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