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Structure paper

TitleSynthesis and structure of 16,22-diketocholesterol bound to oxysterol-binding protein Osh4.
Journal, issue, pagesSteroids, Vol. 78, Page 938-944, Year 2013
Publish dateMay 10, 2012 (structure data deposition date)
AuthorsKoag, M.C. / Cheun, Y. / Kou, Y. / Ouzon-Shubeita, H. / Min, K. / Monzingo, A.F. / Lee, S.
External linksSteroids / PubMed:23756172
MethodsX-ray diffraction
Resolution1.87 - 2 Å
Structure data

PDB-4f4b:
Structure of OSH4 with a cholesterol analog
Method: X-RAY DIFFRACTION / Resolution: 1.87 Å

PDB-4fes:
Structure of OSH4 in complex with cholesterol analogs
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-L39:
(3beta,9beta,25R)-3-hydroxy-26-iodocholest-5-ene-16,22-dione

ChemComp-HOH:
WATER

ChemComp-0T9:
(3S,8S,9S,10R,13S,14S,17R)-3-hydroxy-10,13-dimethyl-17-[(2S,6S)-6-methyl-3-oxooctan-2-yl]-1,2,3,4,7,8,9,10,11,12,13,14,15,17-tetradecahydro-16H-cyclopenta[a]phenanthren-16-one

Source
  • saccharomyces cerevisiae (brewer's yeast)
KeywordsLIPID BINDING PROTEIN / OXYSTEROL / STEROL BINDING PROTEIN

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