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-Structure paper
Title | Synthesis and optimization of substituted furo[2,3-d]-pyrimidin-4-amines and 7H-pyrrolo[2,3-d]pyrimidin-4-amines as ACK1 inhibitors. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 22, Page 6212-6217, Year 2012 |
Publish date | Apr 27, 2012 (structure data deposition date) |
Authors | Jiao, X. / Kopecky, D.J. / Liu, J. / Jaen, J.C. / Cardozo, M.G. / Sharma, R. / Walker, N. / Wesche, H. / Li, S. / Farrelly, E. ...Jiao, X. / Kopecky, D.J. / Liu, J. / Jaen, J.C. / Cardozo, M.G. / Sharma, R. / Walker, N. / Wesche, H. / Li, S. / Farrelly, E. / Xiao, S.H. / Wang, Z. / Kayser, F. |
External links | Bioorg. Med. Chem. Lett. / PubMed:22929232 |
Methods | X-ray diffraction |
Resolution | 2.5 Å |
Structure data | PDB-4ewh: |
Chemicals | ChemComp-T77: ChemComp-HOH: |
Source |
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Keywords | TRANSFERASE/TRANSFERASE INHIBITOR / Drug Design / Enzyme Inhibitors / TRANSFERASE-TRANSFERASE INHIBITOR complex |