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| Title | Structure-based design of novel inhibitors of the MDM2-p53 interaction. |
|---|---|
| Journal, issue, pages | J. Med. Chem., Vol. 55, Page 4936-4954, Year 2012 |
| Publish date | Apr 20, 2012 (structure data deposition date) |
 Authors | Rew, Y. / Sun, D. / Gonzalez-Lopez De Turiso, F. / Bartberger, M.D. / Beck, H.P. / Canon, J. / Chen, A. / Chow, D. / Deignan, J. / Fox, B.M. ...Rew, Y. / Sun, D. / Gonzalez-Lopez De Turiso, F. / Bartberger, M.D. / Beck, H.P. / Canon, J. / Chen, A. / Chow, D. / Deignan, J. / Fox, B.M. / Gustin, D. / Huang, X. / Jiang, M. / Jiao, X. / Jin, L. / Kayser, F. / Kopecky, D.J. / Li, Y. / Lo, M.C. / Long, A.M. / Michelsen, K. / Oliner, J.D. / Osgood, T. / Ragains, M. / Saiki, A.Y. / Schneider, S. / Toteva, M. / Yakowec, P. / Yan, X. / Ye, Q. / Yu, D. / Zhao, X. / Zhou, J. / Medina, J.C. / Olson, S.H. |
 External links | J. Med. Chem. / PubMed:22524527 |
| Methods | X-ray diffraction |
| Resolution | 1.8 - 2 Å |
| Structure data |  PDB-4ere:  PDB-4erf: |
| Chemicals |  ChemComp-0R2:  ChemComp-SO4:  ChemComp-HOH:  ChemComp-0R3: |
| Source |
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 Keywords | Ligase/Ligase inhibitor / MDM2 / p53 / protein-protein interaction / Ligase-Ligase inhibitor complex / protein protein interaction |
homo sapiens (human)