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Structure paper

TitleA Nucleotide-Analogue-Induced Gain of Function Corrects the Error-Prone Nature of Human DNA Polymerase iota.
Journal, issue, pagesJ. Am. Chem. Soc., Vol. 134, Page 10698-10705, Year 2012
Publish dateMar 23, 2012 (structure data deposition date)
AuthorsKetkar, A. / Zafar, M.K. / Banerjee, S. / Marquez, V.E. / Egli, M. / Eoff, R.L.
External linksJ. Am. Chem. Soc. / PubMed:22632140
MethodsX-ray diffraction
Resolution2.1 - 2.901 Å
Structure data

PDB-4ebc:
Conformationally Restrained North-methanocarba-2'-deoxyadenosine Corrects the Error-Prone Nature of Human DNA Polymerase Iota
Method: X-RAY DIFFRACTION / Resolution: 2.901 Å

PDB-4ebd:
Conformationally Restrained North-methanocarba-2'-deoxyadenosine Corrects the Error-Prone Nature of Human DNA Polymerase Iota
Method: X-RAY DIFFRACTION / Resolution: 2.571 Å

PDB-4ebe:
Conformationally Restrained North-methanocarba-2'-deoxyadenosine Corrects the Error-Prone Nature of Human DNA Polymerase Iota
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

Chemicals

ChemComp-0OH:
North-methanocarba-2'-deoxyadenosine triphosphate

ChemComp-CA:
Unknown entry

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

ChemComp-0OJ:
South-methanocarba-2'-deoxyadenosine triphosphate

ChemComp-DTP:
2'-DEOXYADENOSINE 5'-TRIPHOSPHATE

Source
  • homo sapiens (human)
KeywordsTRANSFERASE/DNA / polymerase / TRANSFERASE-DNA complex

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