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-Structure paper
Title | Structural-functional studies of Burkholderia cenocepacia D-glycero-beta-D-manno-heptose 7-phosphate kinase (HldA) and characterization of inhibitors with antibiotic adjuvant and antivirulence properties. |
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Journal, issue, pages | J. Med. Chem., Vol. 56, Page 1405-1417, Year 2013 |
Publish date | Mar 19, 2012 (structure data deposition date) |
Authors | Lee, T.W. / Verhey, T.B. / Antiperovitch, P.A. / Atamanyuk, D. / Desroy, N. / Oliveira, C. / Denis, A. / Gerusz, V. / Drocourt, E. / Loutet, S.A. ...Lee, T.W. / Verhey, T.B. / Antiperovitch, P.A. / Atamanyuk, D. / Desroy, N. / Oliveira, C. / Denis, A. / Gerusz, V. / Drocourt, E. / Loutet, S.A. / Hamad, M.A. / Stanetty, C. / Andres, S.N. / Sugiman-Marangos, S. / Kosma, P. / Valvano, M.A. / Moreau, F. / Junop, M.S. |
External links | J. Med. Chem. / PubMed:23256532 |
Methods | X-ray diffraction |
Resolution | 2.6 - 3.05 Å |
Structure data | PDB-4e84: PDB-4e8w: PDB-4e8y: PDB-4e8z: |
Chemicals | ChemComp-ANP: ChemComp-M7B: ChemComp-K: ChemComp-CL: ChemComp-PO4: ChemComp-MG: ChemComp-GMZ: ChemComp-HOH: ChemComp-IHA: ChemComp-IHC: |
Source |
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Keywords | TRANSFERASE / LPS-heptose Biosynthesis / Beta-clasp dimerization region / PfkB Carbohydrate Kinase / Phosphorylation / Transferase/Transferase Inhibitor / Transferase-Transferase Inhibitor complex |