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TitleThe discovery of potent and selective pyridopyrimidin-7-one based inhibitors of B-Raf(V600E) kinase.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 22, Page 3387-3391, Year 2012
Publish dateMar 13, 2012 (structure data deposition date)
AuthorsRen, L. / Ahrendt, K.A. / Grina, J. / Laird, E.R. / Buckmelter, A.J. / Hansen, J.D. / Newhouse, B. / Moreno, D. / Wenglowsky, S. / Dinkel, V. ...Ren, L. / Ahrendt, K.A. / Grina, J. / Laird, E.R. / Buckmelter, A.J. / Hansen, J.D. / Newhouse, B. / Moreno, D. / Wenglowsky, S. / Dinkel, V. / Gloor, S.L. / Hastings, G. / Rana, S. / Rasor, K. / Risom, T. / Sturgis, H.L. / Voegtli, W.C. / Mathieu, S.
External linksBioorg. Med. Chem. Lett. / PubMed:22534450
MethodsX-ray diffraction
Resolution3.6 Å
Structure data

PDB-4e4x:
Crystal Structure of B-Raf Kinase Domain in Complex with a Dihydropyrido[2,3-d]pyrimidinone-based Inhibitor
Method: X-RAY DIFFRACTION / Resolution: 3.6 Å

Chemicals

ChemComp-T1Q:
N-(2,4-difluoro-3-{2-[(3-hydroxypropyl)amino]-8-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl}phenyl)propane-1-sulfonamide

Source
  • homo sapiens (human)
KeywordsTransferase/Transferase Inhibitor / Kinase / Transferase-Transferase Inhibitor complex

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