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TitleDeciphering Modern Glucocorticoid Cross-pharmacology Using Ancestral Corticosteroid Receptors.
Journal, issue, pagesJ. Biol. Chem., Vol. 287, Page 16267-16275, Year 2012
Publish dateMar 8, 2012 (structure data deposition date)
AuthorsKohn, J.A. / Deshpande, K. / Ortlund, E.A.
External linksJ. Biol. Chem. / PubMed:22437833
MethodsX-ray diffraction
Resolution2.5 Å
Structure data

PDB-4e2j:
X-Ray Crystal Structure of the Ancestral Glucocorticoid Receptor 2 ligand binding domain in complex with mometasone furoate and TIF-2 coactivator fragment
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-MOF:
MOMETASONE FUROATE

ChemComp-FMT:
FORMIC ACID

ChemComp-HOH:
WATER

Source
  • synthetic construct (others)
  • homo sapiens (human)
KeywordsHORMONE/HORMONE ACTIVATOR / nuclear receptor ligand binding domain / glucocorticoid receptor / STEROID BINDING PROTEIN / HORMONE-HORMONE ACTIVATOR complex

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