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Structure paper

TitleNew Class of HIV-1 Integrase (IN) Inhibitors with a Dual Mode of Action.
Journal, issue, pagesJ. Biol. Chem., Vol. 287, Page 21189-21203, Year 2012
Publish dateMar 6, 2012 (structure data deposition date)
AuthorsTsiang, M. / Jones, G.S. / Niedziela-Majka, A. / Kan, E. / Lansdon, E.B. / Huang, W. / Hung, M. / Samuel, D. / Novikov, N. / Xu, Y. ...Tsiang, M. / Jones, G.S. / Niedziela-Majka, A. / Kan, E. / Lansdon, E.B. / Huang, W. / Hung, M. / Samuel, D. / Novikov, N. / Xu, Y. / Mitchell, M. / Guo, H. / Babaoglu, K. / Liu, X. / Geleziunas, R. / Sakowicz, R.
External linksJ. Biol. Chem. / PubMed:22535962
MethodsX-ray diffraction
Resolution1.9 - 2 Å
Structure data

PDB-4e1m:
Crystal Structure of HIV-1 Integrase with a non-catayltic site inhibitor
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

PDB-4e1n:
Crystal Structure of HIV-1 Integrase with a non-catayltic site inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-TQ2:
(2S)-tert-butoxy[4-(3,4-dimethylphenyl)-2-methylquinolin-3-yl]ethanoic acid

ChemComp-HOH:
WATER

ChemComp-TQX:
(2S)-tert-butoxy[4-(8-fluoro-5-methyl-3,4-dihydro-2H-chromen-6-yl)-2-methylquinolin-3-yl]ethanoic acid

Source
  • human immunodeficiency virus type 1
KeywordsTRANSFERASE/TRANSFERASE INHIBITOR / HIV / integrase / TRANSFERASE-TRANSFERASE INHIBITOR complex / HIV-1

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