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TitleAn Optimised Small-Molecule Stabiliser of the 14-3-3-PMA2 Protein-Protein Interaction.
Journal, issue, pagesChemistry, Vol. 18, Page 6520-6527, Year 2012
Publish dateFeb 27, 2012 (structure data deposition date)
AuthorsRichter, A. / Rose, R. / Hedberg, C. / Waldmann, H. / Ottmann, C.
External linksChemistry / PubMed:22467351
MethodsX-ray diffraction
Resolution3.4 Å
Structure data

PDB-4dx0:
Structure of the 14-3-3/PMA2 complex stabilized by a pyrazole derivative
Method: X-RAY DIFFRACTION / Resolution: 3.4 Å

Chemicals

ChemComp-0MT:
4-[(4R)-4-(4-nitrophenyl)-6-oxidanylidene-3-phenyl-1,4-dihydropyrrolo[3,4-c]pyrazol-5-yl]benzoic acid

Source
  • nicotiana tabacum (common tobacco)
  • nicotiana plumbaginifolia (curled-leaved tobacco)
KeywordsPROTEIN BINDING/Hydrolase / 14-3-3 fold / Pyrrolidinones / PROTEIN BINDING-Hydrolase complex

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