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Structure paper

TitleSmall-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 109, Page 5299-5304, Year 2012
Publish dateFeb 19, 2012 (structure data deposition date)
AuthorsMaurer, T. / Garrenton, L.S. / Oh, A. / Pitts, K. / Anderson, D.J. / Skelton, N.J. / Fauber, B.P. / Pan, B. / Malek, S. / Stokoe, D. ...Maurer, T. / Garrenton, L.S. / Oh, A. / Pitts, K. / Anderson, D.J. / Skelton, N.J. / Fauber, B.P. / Pan, B. / Malek, S. / Stokoe, D. / Ludlam, M.J. / Bowman, K.K. / Wu, J. / Giannetti, A.M. / Starovasnik, M.A. / Mellman, I. / Jackson, P.K. / Rudolph, J. / Wang, W. / Fang, G.
External linksProc. Natl. Acad. Sci. USA / PubMed:22431598
MethodsX-ray diffraction
Resolution1.7 - 2.3 Å
Structure data

PDB-4dsn:
Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity
Method: X-RAY DIFFRACTION / Resolution: 2.03 Å

PDB-4dso:
Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity
Method: X-RAY DIFFRACTION / Resolution: 1.85 Å

PDB-4dst:
Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

PDB-4dsu:
Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

Chemicals

ChemComp-GCP:
PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER / GMP-PCP, energy-carrying molecule analogue*YM

ChemComp-MG:
Unknown entry

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

ChemComp-GSP:
5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE

ChemComp-BEN:
BENZAMIDINE

ChemComp-GOL:
GLYCEROL

ChemComp-9LI:
2-(4,6-dichloro-2-methyl-1H-indol-3-yl)ethanamine

ChemComp-DMS:
DIMETHYL SULFOXIDE / DMSO, precipitant*YM

ChemComp-ACT:
ACETATE ION

ChemComp-GDP:
GUANOSINE-5'-DIPHOSPHATE / GDP, energy-carrying molecule*YM

ChemComp-BZI:
BENZIMIDAZOLE

Source
  • homo sapiens (human)
KeywordsHYDROLASE / Small G-protein / signaling

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