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-Structure paper
| Title | Structure-based macrocyclization yields hepatitis C virus NS5B inhibitors with improved binding affinities and pharmacokinetic properties. |
|---|---|
| Journal, issue, pages | Angew. Chem. Int. Ed. Engl., Vol. 51, Page 4637-4640, Year 2012 |
| Publish date | Feb 17, 2012 (structure data deposition date) |
 Authors | Cummings, M.D. / Lin, T.I. / Hu, L. / Tahri, A. / McGowan, D. / Amssoms, K. / Last, S. / Devogelaere, B. / Rouan, M.C. / Vijgen, L. ...Cummings, M.D. / Lin, T.I. / Hu, L. / Tahri, A. / McGowan, D. / Amssoms, K. / Last, S. / Devogelaere, B. / Rouan, M.C. / Vijgen, L. / Berke, J.M. / Dehertogh, P. / Fransen, E. / Cleiren, E. / van der Helm, L. / Fanning, G. / Van Emelen, K. / Nyanguile, O. / Simmen, K. / Raboisson, P. / Vendeville, S. |
 External links | Angew. Chem. Int. Ed. Engl. / PubMed:22473861 |
| Methods | X-ray diffraction |
| Resolution | 2.1 Å |
| Structure data |  PDB-4dru: |
| Chemicals |  ChemComp-0LN:  ChemComp-SO4:  ChemComp-GOL:  ChemComp-HOH: |
| Source |
|
 Keywords | Transferase/Inhibitor / HCV POLYMERASE / macrocycle inhibitor / thumb domain / Transferase-Inhibitor complex |
hepatitis c virus