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-Structure paper
Title | Malarial dihydrofolate reductase as a paradigm for drug development against a resistance-compromised target |
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Journal, issue, pages | Proc. Natl. Acad. Sci. USA, Vol. 109, Page 16823-16828, Year 2012 |
Publish date | Jan 19, 2012 (structure data deposition date) |
![]() | Yuthavong, Y. / Tarnchompoo, B. / Vilaivan, T. / Chitnumsub, P. / Kamchonwongpaisan, S. / Charman, S.A. / McLennan, D.N. / White, K.L. / Vivas, L. / Bongard, E. ...Yuthavong, Y. / Tarnchompoo, B. / Vilaivan, T. / Chitnumsub, P. / Kamchonwongpaisan, S. / Charman, S.A. / McLennan, D.N. / White, K.L. / Vivas, L. / Bongard, E. / Thongphanchang, C. / Taweechai, S. / Vanichtanankul, J. / Rattanajak, R. / Arwon, U. / Fantauzzi, P. / Yuvaniyama, J. / Charman, W.N. / Matthews, D. |
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Methods | X-ray diffraction |
Resolution | 2.05 - 2.5 Å |
Structure data | ![]() PDB-4ddr: ![]() PDB-4dp3: ![]() PDB-4dpd: ![]() PDB-4dph: |
Chemicals | ![]() ChemComp-NDP: ![]() ChemComp-MMV: ![]() ChemComp-HOH: ![]() ChemComp-PO4: ![]() ChemComp-DHF: ![]() ChemComp-NAP: ![]() ChemComp-UMP: ![]() ChemComp-P65: ![]() ChemComp-BME: |
Source |
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![]() | OXIDOREDUCTASE/OXIDOREDUCTASE INHIBITOR / antifolate / NADPH / OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex / OXIDOREDUCTASE / TRANSFERASE/INHIBITOR / Rossmann fold / Reductase / TRANSFERASE-INHIBITOR complex / TRANSFERASE / DHFR / NADPH binding / Plasmodium falciparum |