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-Structure paper
Title | HIV-1 Reverse Transcriptase (RT) Polymorphism 172K Suppresses the Effect of Clinically Relevant Drug Resistance Mutations to Both Nucleoside and Non-nucleoside RT Inhibitors. |
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Journal, issue, pages | J. Biol. Chem., Vol. 287, Page 29988-29999, Year 2012 |
Publish date | Jan 24, 2012 (structure data deposition date) |
![]() | Hachiya, A. / Marchand, B. / Kirby, K.A. / Michailidis, E. / Tu, X. / Palczewski, K. / Ong, Y.T. / Li, Z. / Griffin, D.T. / Schuckmann, M.M. ...Hachiya, A. / Marchand, B. / Kirby, K.A. / Michailidis, E. / Tu, X. / Palczewski, K. / Ong, Y.T. / Li, Z. / Griffin, D.T. / Schuckmann, M.M. / Tanuma, J. / Oka, S. / Singh, K. / Kodama, E.N. / Sarafianos, S.G. |
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Methods | X-ray diffraction |
Resolution | 2.15 Å |
Structure data | ![]() PDB-4dg1: |
Chemicals | ![]() ChemComp-MG: ![]() ChemComp-EDO: ![]() ChemComp-GOL: ![]() ChemComp-HOH: |
Source |
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![]() | TRANSFERASE / Polymorphism 172K / P51/P66 / HETERO DIMER / AIDS / HIV / RESISTANCE MUTATIONS / right-hand configuration / RNase H domain / Reverse transcriptase / ribonuclease H / RNA-DIRECTED DNA POLYMERASE / DNA POLYMERASE / AZT excision / AZT unblocking / nevirapine / efavirenz / AZT / NUCLEOSIDE INHIBITORS / Nonnucleoside Inhibitors / NRTI / NNRTI |