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-Structure paper
Title | Discovery and optimization of a potent and selective triazolopyridinone series of c-Met inhibitors. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 22, Page 4089-4093, Year 2012 |
Publish date | Jan 20, 2012 (structure data deposition date) |
![]() | Bode, C.M. / Boezio, A.A. / Albrecht, B.K. / Bellon, S.F. / Berry, L. / Broome, M.A. / Choquette, D. / Dussault, I. / Lewis, R.T. / Lin, M.H. ...Bode, C.M. / Boezio, A.A. / Albrecht, B.K. / Bellon, S.F. / Berry, L. / Broome, M.A. / Choquette, D. / Dussault, I. / Lewis, R.T. / Lin, M.H. / Rex, K. / Whittington, D.A. / Yang, Y. / Harmange, J.C. |
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Methods | X-ray diffraction |
Resolution | 2 - 2.05 Å |
Structure data | ![]() PDB-4deg: ![]() PDB-4deh: ![]() PDB-4dei: |
Chemicals | ![]() ChemComp-0JJ: ![]() ChemComp-HOH: ![]() ChemComp-0JK: ![]() ChemComp-0JL: |
Source |
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![]() | TRANSFERASE/TRANSFERASE INHIBITOR / proto-oncogene / receptor tyrosine kinase / RTK / ATP-binding / hepatocyte growth factor/scatter factor / HGF/SF / phosphoprotein / TRANSFERASE-TRANSFERASE INHIBITOR complex / inhibitor |