+Search query
-Structure paper
Title | Design and synthesis of novel DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitors. 1. Exploration of [5,6]-fused bicyclic scaffolds |
---|---|
Journal, issue, pages | J. Med. Chem., Vol. 55, Page 3452-3478, Year 2012 |
Publish date | Jan 17, 2012 (structure data deposition date) |
![]() | Okaniwa, M. / Hirose, M. / Imada, T. / Ohashi, T. / Hayashi, Y. / Miyazaki, T. / Arita, T. / Yabuki, M. / Kakoi, K. / Kato, J. ...Okaniwa, M. / Hirose, M. / Imada, T. / Ohashi, T. / Hayashi, Y. / Miyazaki, T. / Arita, T. / Yabuki, M. / Kakoi, K. / Kato, J. / Takagi, T. / Kawamoto, T. / Yao, S. / Sumita, A. / Tsutsumi, S. / Tottori, T. / Oki, H. / Sang, B.C. / Yano, J. / Aertgeerts, K. / Yoshida, S. / Ishikawa, T. |
![]() | ![]() ![]() |
Methods | X-ray diffraction |
Resolution | 1.64 - 3.15 Å |
Structure data | ![]() PDB-3vnt: ![]() PDB-4dbn: |
Chemicals | ![]() ChemComp-0JA: ![]() ChemComp-EDO: ![]() ChemComp-HOH: |
Source |
|
![]() | TRANSFERASE/TRANSFERASE INHIBITOR / vegfr2 / kinase domain / Tyrosin-protein kinase / TRANSFERASE-TRANSFERASE INHIBITOR complex / kinase drug complex / Ser/Thr Kinase / ATP Binding / Phosphorylation |