+Search query
-Structure paper
Title | Rational Design of Broad Spectrum Antibacterial Activity Based on a Clinically Relevant Enoyl-Acyl Carrier Protein (Acp) Reductase Inhibitor. |
---|---|
Journal, issue, pages | J. Biol. Chem., Vol. 289, Page 15987-, Year 2014 |
Publish date | Apr 29, 2013 (structure data deposition date) |
Authors | Schiebel, J. / Chang, A. / Shah, S. / Lu, Y. / Liu, L. / Pan, P. / Hirschbeck, M.W. / Tareilus, M. / Eltschkner, S. / Yu, W. ...Schiebel, J. / Chang, A. / Shah, S. / Lu, Y. / Liu, L. / Pan, P. / Hirschbeck, M.W. / Tareilus, M. / Eltschkner, S. / Yu, W. / Cummings, J.E. / Knudson, S.E. / Bommineni, G.R. / Walker, S.G. / Slayden, R.A. / Sotriffer, C.A. / Tonge, P.J. / Kisker, C. |
External links | J. Biol. Chem. / PubMed:24739388 |
Methods | X-ray diffraction |
Resolution | 1.8 - 3.1 Å |
Structure data | PDB-4bku: PDB-4cuz: PDB-4cv0: PDB-4cv1: PDB-4cv2: PDB-4cv3: |
Chemicals | ChemComp-NAI: ChemComp-1S5: ChemComp-HOH: ChemComp-AEW: ChemComp-NDP: ChemComp-SO4: ChemComp-PT6: ChemComp-EDO: ChemComp-CL: ChemComp-VT4: |
Source |
|
Keywords | OXIDOREDUCTASE / FATTY ACID BIOSYNTHESIS / ENOYL- ACP REDUCTASE / PYRIDONE / SHORT-CHAIN DEHYDROGENASE/REDUCTASE SUPERFAMILY / LIPID SYNTHESIS / SAFABI / ENOYL-ACP REDUCTASE / ECFABI |