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-Structure paper
Title | Structure-Based Design and Development of Functionalized Mercaptoguanine Derivatives as Inhibitors of the Folate Biosynthesis Pathway Enzyme 6-Hydroxymethyl-7,8-Dihydropterin Pyrophosphokinase from Staphylococcus Aureus. |
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Journal, issue, pages | J. Med. Chem., Vol. 57, Page 9612-, Year 2014 |
Publish date | Feb 27, 2014 (structure data deposition date) |
![]() | Dennis, M.L. / Chhabra, S. / Wang, Z. / Debono, A. / Dolezal, O. / Newman, J. / Pitcher, N.P. / Rahmani, R. / Cleary, B. / Barlow, N. ...Dennis, M.L. / Chhabra, S. / Wang, Z. / Debono, A. / Dolezal, O. / Newman, J. / Pitcher, N.P. / Rahmani, R. / Cleary, B. / Barlow, N. / Hattarki, M. / Graham, B. / Peat, T.S. / Baell, J.B. / Swarbrick, J.D. |
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Methods | X-ray diffraction |
Resolution | 1.56 - 2.7 Å |
Structure data | ![]() PDB-4crj: ![]() PDB-4cwb: ![]() PDB-4cyu: |
Chemicals | ![]() ChemComp-APC: ![]() ChemComp-MG: ![]() ChemComp-NO3: ![]() ChemComp-YH5: ![]() ChemComp-HOH: ![]() ChemComp-X6L: ![]() ChemComp-TRS: |
Source |
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![]() | TRANSFERASE / FOLATE / STRUCTURE-BASED DRUG DESIGN / S.AUREUS |