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Structure paper

TitleEnzymatic Synthesis of Acyclic Nucleoside Thiophosphonate Diphosphates: Effect of the Alpha-Phosphorus Configuration on HIV-1 RT Activity.
Journal, issue, pagesAntiviral Res., Vol. 117, Page 122-, Year 2015
Publish dateSep 18, 2013 (structure data deposition date)
AuthorsPriet, S. / Roux, L. / Saez-Ayala, M. / Ferron, F. / Canard, B. / Alvarez, K.
External linksAntiviral Res. / PubMed:25766862
MethodsX-ray diffraction
Resolution1.25 - 2.32 Å
Structure data

PDB-4c6a:
High Resolution Structure of the Nucleoside diphosphate kinase
Method: X-RAY DIFFRACTION / Resolution: 1.25 Å

PDB-4cp5:
ndpK in complex with (Rp)-SPMPApp
Method: X-RAY DIFFRACTION / Resolution: 2.32 Å

Chemicals

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-HOH:
WATER

ChemComp-EOI:
[[(2R)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethyl-sulfanyl-phosphoryl] phosphono hydrogen phosphate

Source
  • dictyostelium discoideum (eukaryote)
KeywordsTRANSFERASE / PHOSPHOTRANSFERASE

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