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TitleDiscovery of the Fibrinolysis Inhibitor Azd6564, Acting Via Interference of a Protein-Protein Interaction.
Journal, issue, pagesAcs Med. Chem. Lett., Vol. 5, Page 538-, Year 2014
Publish dateDec 10, 2013 (structure data deposition date)
AuthorsCheng, L. / Pettersen, D. / Ohlsson, B. / Schell, P. / Karle, M. / Evertsson, E. / Pahlen, S. / Jonforsen, M. / Plowright, A.T. / Bostrom, J. ...Cheng, L. / Pettersen, D. / Ohlsson, B. / Schell, P. / Karle, M. / Evertsson, E. / Pahlen, S. / Jonforsen, M. / Plowright, A.T. / Bostrom, J. / Fex, T. / Thelin, A. / Hilgendorf, C. / Xue, Y. / Wahlund, G. / Lindberg, W. / Larsson, L. / Gustafsson, D.
External linksAcs Med. Chem. Lett. / PubMed:24900876
MethodsX-ray diffraction
Resolution1.78 Å
Structure data

PDB-4cik:
plasminogen kringle 1 in complex with inhibitor
Method: X-RAY DIFFRACTION / Resolution: 1.78 Å

Chemicals

ChemComp-XO3:
5-[(2R,4S)-2-(phenylmethyl)piperidin-4-yl]-1,2-oxazol-3-one

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE / FIBRINOLYSIS / PLASMINOGEN / PROTEIN-PROTEIN INTERACTION / KRINGLE LIGAND

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