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-Structure paper
Title | Optimization of Brain Penetrant 11Beta-Hydroxysteroid Dehydrogenase Type I Inhibitors and in Vivo Testing in Diet- Induced Obese Mice. |
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Journal, issue, pages | J. Med. Chem., Vol. 57, Page 970-, Year 2014 |
Publish date | Sep 23, 2013 (structure data deposition date) |
![]() | Goldberg, F.W. / Dossetter, A.G. / Scott, J.S. / Robb, G.R. / Boyd, S. / Groombridge, S.D. / Kemmitt, P.D. / Sjogren, T. / Gutierrez, P.M. / Deschoolmeester, J. ...Goldberg, F.W. / Dossetter, A.G. / Scott, J.S. / Robb, G.R. / Boyd, S. / Groombridge, S.D. / Kemmitt, P.D. / Sjogren, T. / Gutierrez, P.M. / Deschoolmeester, J. / Swales, J.G. / Turnbull, A.V. / Wild, M.J. |
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Methods | X-ray diffraction |
Resolution | 1.91 - 2.16 Å |
Structure data | ![]() PDB-4c7j: ![]() PDB-4c7k: |
Chemicals | ![]() ChemComp-NAP: ![]() ChemComp-4YQ: ![]() ChemComp-HOH: ![]() ChemComp-DZL: |
Source |
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![]() | OXIDOREDUCTASE / CNS PENETRATION / STRUCTURE-BASED DESIGN |