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Structure paper

TitleDiscovery of 1-Methyl-1H-Imidazole Derivatives as Potent Jak2 Inhibitors.
Journal, issue, pagesJ. Med. Chem., Vol. 57, Page 144-, Year 2014
Publish dateSep 17, 2013 (structure data deposition date)
AuthorsSu, Q. / Ioannidis, S. / Chuaqui, C. / Almeida, L. / Alimzhanov, M. / Bebernitz, G. / Bell, K. / Block, M. / Howard, T. / Huang, S. ...Su, Q. / Ioannidis, S. / Chuaqui, C. / Almeida, L. / Alimzhanov, M. / Bebernitz, G. / Bell, K. / Block, M. / Howard, T. / Huang, S. / Huszar, D. / Read, J.A. / Rivard Costa, C. / Shi, J. / Su, M. / Ye, M. / Zinda, M.
External linksJ. Med. Chem. / PubMed:24359159
MethodsX-ray diffraction
Resolution2.45 - 2.75 Å
Structure data

PDB-4c61:
Inhibitors of Jak2 Kinase domain
Method: X-RAY DIFFRACTION / Resolution: 2.45 Å

PDB-4c62:
Inhibitors of Jak2 Kinase domain
Method: X-RAY DIFFRACTION / Resolution: 2.75 Å

Chemicals

ChemComp-LMM:
N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-7-methyl-N4-(1-methylimidazol-4-yl)thieno[3,2-d]pyrimidine-2,4-diamine

ChemComp-ACT:
ACETATE ION

ChemComp-HOH:
WATER

ChemComp-XWW:
N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-n4-(1-methylimidazol-4-yl)-6-morpholino-1,3,5-triazine-2,4-diamine

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / KINASE

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