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Structure paper

TitleMechanism of Allosteric Activation of Samhd1 by Dgtp
Journal, issue, pagesNat. Struct. Mol. Biol., Vol. 20, Page 1304-, Year 2013
Publish dateJul 25, 2013 (structure data deposition date)
AuthorsJi, X. / Wu, Y. / Yan, J. / Mehrens, J. / Yang, H. / Delucia, M. / Hao, C. / Gronenborn, A.M. / Skowronski, J. / Ahn, J. / Xiong, Y.
External linksNat. Struct. Mol. Biol. / PubMed:24141705
MethodsX-ray diffraction
Resolution1.83 - 2.88 Å
Structure data

PDB-4bzb:
Crystal structure of the tetrameric dGTP-bound SAMHD1 mutant catalytic core
Method: X-RAY DIFFRACTION / Resolution: 1.83 Å

PDB-4bzc:
Crystal structure of the tetrameric dGTP-bound wild type SAMHD1 catalytic core
Method: X-RAY DIFFRACTION / Resolution: 2.88 Å

Chemicals

ChemComp-DGT:
2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE

ChemComp-MG:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-T8T:
2'-deoxyguanosine-5'-O-(1-thiotriphosphate)

ChemComp-MN:
Unknown entry

Source
  • homo sapiens (human)
KeywordsHYDROLASE / HIV RESTRICTION FACTOR / DNTPASE

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