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TitleAurora Isoform Selectivity: Design and Synthesis of Imidazo[4,5-B]Pyridine Derivatives as Highly Selective Inhibitors of Aurora-A Kinase in Cells.
Journal, issue, pagesJ. Med. Chem., Vol. 56, Page 9122-, Year 2013
Publish dateJul 19, 2013 (structure data deposition date)
AuthorsBavetsias, V. / Faisal, A. / Crumpler, S. / Brown, N. / Kosmopoulou, M. / Joshi, A. / Atrash, B. / Perez-Fuertes, Y. / Schmitt, J.A. / Boxall, K.J. ...Bavetsias, V. / Faisal, A. / Crumpler, S. / Brown, N. / Kosmopoulou, M. / Joshi, A. / Atrash, B. / Perez-Fuertes, Y. / Schmitt, J.A. / Boxall, K.J. / Burke, R. / Sun, C. / Avery, S. / Bush, K. / Henley, A. / Raynaud, F.I. / Workman, P. / Bayliss, R. / Linardopoulos, S. / Blagg, J.
External linksJ. Med. Chem. / PubMed:24195668
MethodsX-ray diffraction
Resolution2.6 - 2.75 Å
Structure data

PDB-4byi:
Aurora A kinase bound to a highly selective imidazopyridine inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

PDB-4byj:
Aurora A kinase bound to a highly selective imidazopyridine inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2.75 Å

Chemicals

ChemComp-FH3:
(S)-N-((1-(6-chloro-2-(1,3-dimethyl-1H-pyrazol-4-yl)-3H-imidazo[4,5-b]pyridin-7-yl)pyrrolidin-3-yl)methyl)acetamide

ChemComp-FH5:
(S)-N-(1-(6-chloro-2-(1,3-dimethyl-1H-pyrazol-4-yl)-3H-imidazo[4,5-b]pyridin-7-yl)pyrrolidin-3-yl)acetamide

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / CELL CYCLE / INHIBITOR

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