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TitleBet Inhibition Silences Expression of Mycn and Bcl2 and Induces Cytotoxicity in Neuroblastoma Tumor Models.
Journal, issue, pagesPlos One, Vol. 8, Page 72967-, Year 2013
Publish dateApr 20, 2013 (structure data deposition date)
AuthorsWyce, A. / Ganji, G. / Smitheman, K.N. / Chung, C. / Korenchuk, S. / Bai, Y. / Barbash, O. / Le, B. / Craggs, P.D. / Mccabe, M.T. ...Wyce, A. / Ganji, G. / Smitheman, K.N. / Chung, C. / Korenchuk, S. / Bai, Y. / Barbash, O. / Le, B. / Craggs, P.D. / Mccabe, M.T. / Kennedy-Wilson, K.M. / Sanchez, L.V. / Gosmini, R.L. / Parr, N. / Mchugh, C.F. / Dhanak, D. / Prinjha, R.K. / Auger, K.R. / Tummino, P.J.
External linksPlos One / PubMed:24009722
MethodsX-ray diffraction
Resolution1.59 Å
Structure data

PDB-4bjx:
N-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH GSK1324726A (I-BET726)
Method: X-RAY DIFFRACTION / Resolution: 1.59 Å

Chemicals

ChemComp-73B:
4-[(2S,4R)-1-acetyl-4-[(4-chlorophenyl)amino]-2-methyl-1,2,3,4-tetrahydroquinolin-6-yl]benzoic acid

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsDNA BINDING PROTEIN / INHIBITOR / HISTONE / EPIGENETIC READER

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