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| Title | Discovery and Optimization of Pyrimidone Indoline Amide Pi3Kbeta Inhibitors for the Treatment of Phosphatase and Tensin Homologue (Pten)-Deficient Cancers. |
|---|---|
| Journal, issue, pages | J. Med. Chem., Vol. 57, Page 903-, Year 2014 |
| Publish date | Mar 22, 2013 (structure data deposition date) |
 Authors | Certal, V. / Carry, J.B. / Halley, F. / Virone-Oddos, A. / Thompson, F. / Filoche-Romme, B. / El-Ahmad, Y. / Karlsson, A. / Charrier, V. / Delorme, C. ...Certal, V. / Carry, J.B. / Halley, F. / Virone-Oddos, A. / Thompson, F. / Filoche-Romme, B. / El-Ahmad, Y. / Karlsson, A. / Charrier, V. / Delorme, C. / Rak, A. / Abecassis, P. / Amara, C. / Vincent, L. / Bonnevaux, H. / Nicolas, J. / Mathieu, M. / Bertrand, T. / Marquette, J. / Michot, N. / Benard, T. / Perrin, M. / Lemaitre, O. / Guerif, S. / Perron, S. / Monget, S. / Gruss-Leleu, F. / Doerflinger, G. / Guizani, H. / Brollo, M. / Delbarre, L. / Bertin, L. / Richepin, P. / Loyau, V. / Garcia-Echeverria, C. / Lengauer, C. / Schio, L. |
 External links | J. Med. Chem. / PubMed:24387221 |
| Methods | X-ray diffraction |
| Resolution | 2.8 Å |
| Structure data |  PDB-4bfr: |
| Chemicals |  ChemComp-J82:  ChemComp-HOH: |
| Source |
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 Keywords | TRANSFERASE / INHIBITOR |
mus musculus (house mouse)