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-Structure paper
Title | Discovery of a Potent, Selective and Orally Active Pde10A Inhibitor for the Potential Treatment of Schizophrenia. |
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Journal, issue, pages | J. Med. Chem., Vol. 57, Page 4196-, Year 2014 |
Publish date | Sep 28, 2012 (structure data deposition date) |
![]() | Bartolome-Nebreda, J.M. / Delgado, F. / Martin, M.L. / Martinez-Viturro, C.M. / Pastor, J. / Tong, H.M. / Iturrino, L. / Macdonald, G.J. / Sanderson, W.E. / Megens, A. ...Bartolome-Nebreda, J.M. / Delgado, F. / Martin, M.L. / Martinez-Viturro, C.M. / Pastor, J. / Tong, H.M. / Iturrino, L. / Macdonald, G.J. / Sanderson, W.E. / Megens, A. / Langlois, X. / Somers, M. / Vanhoof, G. / Conde Ceide, S. |
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Methods | X-ray diffraction |
Resolution | 2.5 Å |
Structure data | ![]() PDB-4bbx: |
Chemicals | ![]() ChemComp-LKF: ![]() ChemComp-ZN: ![]() ChemComp-MG: ![]() ChemComp-HOH: |
Source |
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![]() | HYDROLASE / PHOSPHODIESTERASE INHIBITOR / INHIBITOR COMPLEX / ZINC BINDING / MAGNESIUM BINDING |