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| Title | Sar and in Vivo Evaluation of 4-Aryl-2-Aminoalkylpyrimidines as Potent and Selective Janus Kinase 2 (Jak2) Inhibitors |
|---|---|
| Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 22, Page 7653-, Year 2012 |
| Publish date | Sep 21, 2012 (structure data deposition date) |
 Authors | Forsyth, T. / Kearney, P.C. / Kim, B.G. / Johnson, H.W.B. / Aay, N. / Arcalas, A. / Brown, D.S. / Chan, V. / Chen, J. / Du, H. ...Forsyth, T. / Kearney, P.C. / Kim, B.G. / Johnson, H.W.B. / Aay, N. / Arcalas, A. / Brown, D.S. / Chan, V. / Chen, J. / Du, H. / Epshteyn, S. / Galan, A.A. / Huynh, T.P. / Ibrahim, M.A. / Kane, B. / Koltun, E. / Mann, G. / Meyr, L.E. / Lee, M.S. / Lewis, G.L. / Noguchi, R.T. / Pack, M. / Ridgway, B.H. / Shi, X. / Takeuchi, C.S. / Zu, P. / Leahy, J.W. / Nuss, J.M. / Aoyama, R. / Engst, S. / Gendreau, S.B. / Kassees, R. / Li, J. / Lin, S.-H. / Martini, J.-F. / Stout, T. / Tong, P. / Woolfrey, J. / Zhang, W. / Yu, P. |
 External links | Bioorg. Med. Chem. Lett. / PubMed:23127890 |
| Methods | X-ray diffraction |
| Resolution | 1.9 - 2 Å |
| Structure data |  PDB-4bbe:  PDB-4bbf: |
| Chemicals |  ChemComp-3O4:  ChemComp-HOH:  ChemComp-O19: |
| Source |
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 Keywords | TRANSFERASE / INHIBITOR |
homo sapiens (human)