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-Structure paper
Title | New aminoimidazoles as beta-secretase (BACE-1) inhibitors showing amyloid-beta (A beta ) lowering in brain. |
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Journal, issue, pages | J. Med. Chem., Vol. 55, Page 9297-9311, Year 2012 |
Publish date | Jul 10, 2012 (structure data deposition date) |
![]() | Gravenfors, Y. / Viklund, J. / Blid, J. / Ginman, T. / Karlstrom, S. / Kihlstrom, J. / Kolmodin, K. / Lindstrom, J. / von Berg, S. / von Kieseritzky, F. ...Gravenfors, Y. / Viklund, J. / Blid, J. / Ginman, T. / Karlstrom, S. / Kihlstrom, J. / Kolmodin, K. / Lindstrom, J. / von Berg, S. / von Kieseritzky, F. / Bogar, K. / Slivo, C. / Swahn, B.M. / Olsson, L.L. / Johansson, P. / Eketjall, S. / Falting, J. / Jeppsson, F. / Stromberg, K. / Janson, J. / Rahm, F. |
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Methods | X-ray diffraction |
Resolution | 1.95 Å |
Structure data | ![]() PDB-4b1c: ![]() PDB-4b1d: ![]() PDB-4b1e: |
Chemicals | ![]() ChemComp-DMS: ![]() ChemComp-1B1: ![]() ChemComp-HOH: ![]() ChemComp-ACT: ![]() ChemComp-6TG: ![]() ChemComp-6T6: |
Source |
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![]() | HYDROLASE / LEAD GENERATION / STRUCTURE-BASED DRUG DESIGN / INHIBITOR |