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TitleCharacterization of a Small Molecule Inhibitor of Plasminogen Activator Inhibitor Type 1 that Accelerates the Transition Into the Latent Conformation
Journal, issue, pagesJ. Biol. Chem., Vol. 288, Page 873-, Year 2013
Publish dateApr 17, 2012 (structure data deposition date)
AuthorsFjellstrom, O. / Deinum, J. / Sjogren, T. / Johansson, C. / Geschwindner, S. / Nerme, V. / Legnehed, A. / Mcpheat, J. / Olsson, K. / Bodin, C. ...Fjellstrom, O. / Deinum, J. / Sjogren, T. / Johansson, C. / Geschwindner, S. / Nerme, V. / Legnehed, A. / Mcpheat, J. / Olsson, K. / Bodin, C. / Panuovic, A. / Gustafsson, D.
External linksJ. Biol. Chem. / PubMed:23155046
MethodsX-ray diffraction
Resolution2.4 Å
Structure data

PDB-4aqh:
Plasminogen activator inhibitor type-1 in complex with the inhibitor AZ3976
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

Chemicals

ChemComp-TB7:
TERT-BUTYL 3-[(4-OXO-3H-PYRIDO[2,3-D]PYRIMIDIN-2-YL)AMINO]AZETIDINE-1-CARBOXYLATE

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDOLASE INHIBITOR / LATENT FORM

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