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TitleDiscovery of Disubstituted Imidazo[4,5-B]Pyridines and Purines as Potent Trka Inhibitors
Journal, issue, pagesAcs Med. Chem. Lett., Vol. 3, Page 705-, Year 2012
Publish dateMar 28, 2012 (structure data deposition date)
AuthorsWang, T. / Lamb, M.L. / Block, M.H. / Davies, A.M. / Han, Y. / Hoffmann, E. / Ioannidis, S. / Josey, J.A. / Liu, Z. / Lyne, P.D. ...Wang, T. / Lamb, M.L. / Block, M.H. / Davies, A.M. / Han, Y. / Hoffmann, E. / Ioannidis, S. / Josey, J.A. / Liu, Z. / Lyne, P.D. / Macintyre, T. / Mohr, P.J. / Omer, C.A. / Sjogren, T. / Thress, K. / Wang, B. / Wang, H. / Yu, D. / Zhang, H.
External linksAcs Med. Chem. Lett. / PubMed:24900538
MethodsX-ray diffraction
Resolution2.75 Å
Structure data

PDB-4aoj:
Human TrkA in complex with the inhibitor AZ-23
Method: X-RAY DIFFRACTION / Resolution: 2.75 Å

Chemicals

ChemComp-V4Z:
5-chloranyl-N2-[(1S)-1-(5-fluoranylpyridin-2-yl)ethyl]-N4-(3-propan-2-yloxy-1H-pyrazol-5-yl)pyrimidine-2,4-diamine

ChemComp-ZN:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / INHIBITOR

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