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-Structure paper
Title | Discovery of a Small-Molecule Type II Inhibitor of Wild-Type and Gatekeeper Mutants of Bcr-Abl, Pdgfralpha, Kit, and Src Kinases: Novel Type II Inhibitor of Gatekeeper Mutants. |
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Journal, issue, pages | Blood, Vol. 115, Page 4206-, Year 2010 |
Publish date | Feb 1, 2012 (structure data deposition date) |
Authors | Weisberg, E. / Choi, H.G. / Ray, A. / Barrett, R. / Zhang, J. / Sim, T. / Zhou, W. / Seeliger, M. / Cameron, M. / Azam, M. ...Weisberg, E. / Choi, H.G. / Ray, A. / Barrett, R. / Zhang, J. / Sim, T. / Zhou, W. / Seeliger, M. / Cameron, M. / Azam, M. / Fletcher, J.A. / Debiec-Rychter, M. / Mayeda, M. / Moreno, D. / Kung, A.L. / Janne, P.A. / Khosravi-Far, R. / Melo, J.V. / Manley, P.W. / Adamia, S. / Wu, C. / Gray, N. / Griffin, J.D. |
External links | Blood / PubMed:20299508 |
Methods | X-ray diffraction |
Resolution | 2.6 Å |
Structure data | PDB-4agw: |
Chemicals | ChemComp-NG7: ChemComp-MES: ChemComp-GOL: ChemComp-HOH: |
Source |
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Keywords | TRANSFERASE / ATP-BINDING / LIPOPROTEIN / MYRISTATE / PHOSPHOPROTEIN / SH2 DOMAIN / SH3 DOMAIN |