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-Structure paper
Title | The Discovery of N-Cyclopropyl-4-Methyl-3-[6--(4-Methylpiperazin-1-Yl-4-Oxoquinazolin-3(4H)-Yl]Benzamide (Azd6703), a Clinical P38Alpha Map Kinase Inhibitor for the Treatment of Inflammatory Diseases |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 22, Page 3879-, Year 2012 |
Publish date | Nov 29, 2011 (structure data deposition date) |
Authors | Brown, D.S. / Cumming, J.G. / Bethel, P. / Finlayson, J. / Gerhardt, S. / Nash, I. / Pauptit, R. / Pike, K.G. / Reid, A. / Snelson, W. ...Brown, D.S. / Cumming, J.G. / Bethel, P. / Finlayson, J. / Gerhardt, S. / Nash, I. / Pauptit, R. / Pike, K.G. / Reid, A. / Snelson, W. / Swallow, S. / Thompson, C. |
External links | Bioorg. Med. Chem. Lett. / PubMed:22608965 |
Methods | X-ray diffraction |
Resolution | 1.8 - 2.5 Å |
Structure data | PDB-4a9y: PDB-4aa0: PDB-4aa4: PDB-4aa5: PDB-4aac: |
Chemicals | ChemComp-AQZ: ChemComp-HOH: ChemComp-AA0: ChemComp-QC0: ChemComp-NQB: ChemComp-AAV: ChemComp-CL: |
Source |
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Keywords | TRANSFERASE / SERINE/THREONINE KINASE |