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TitleRegulation of Lipid Binding Underlies the Activation Mechanism of Class Ia Pi3-Kinases.
Journal, issue, pagesOncogene, Vol. 31, Page 3655-, Year 2012
Publish dateOct 24, 2011 (structure data deposition date)
AuthorsHon, W.-C. / Berndt, A. / Williams, R.L.
External linksOncogene / PubMed:22120714
MethodsX-ray diffraction
Resolution3.5 Å
Structure data

PDB-4a55:
Crystal structure of p110alpha in complex with iSH2 of p85alpha and the inhibitor PIK-108
Method: X-RAY DIFFRACTION / Resolution: 3.5 Å

Chemicals

ChemComp-P08:
PIK-108

Source
  • mus musculus (house mouse)
  • homo sapiens (human)
KeywordsTRANSFERASE / ONCOGENE / LIPID KINASE / MEMBRANE BINDING / CANCER MUTATIONS / TUMOURS / GROWTH FACTOR SIGNALLING / PI3-KINASE INHIBITOR / NON-ATP COMPETITIVE LIGAND BINDING SITE / STRUCTURE-ACTIVITY RELATIONSHIP / ENZYME REGULATION

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