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TitleCrystal structure of the topoisomerase II poison 9-amino-[N-(2-dimethylamino)ethyl]acridine-4-carboxamide bound to the DNA hexanucleotide d(CGTACG)2.
Journal, issue, pagesBiochemistry, Vol. 38, Page 9221-9233, Year 1999
Publish dateApr 14, 1999 (structure data deposition date)
AuthorsAdams, A. / Guss, J.M. / Collyer, C.A. / Denny, W.A. / Wakelin, L.P.
External linksBiochemistry / PubMed:10413496
MethodsX-ray diffraction
Resolution1.6 Å
Structure data

PDB-465d:
STRUCTURE OF THE TOPOISOMERASE II POISON BOUND TO DNA
Method: X-RAY DIFFRACTION / Resolution: 1.6 Å

Chemicals

ChemComp-9AD:
9-AMINO-(N-(2-DIMETHYLAMINO)ETHYL)ACRIDINE-4-CARBOXAMIDE

ChemComp-HOH:
WATER

KeywordsDNA / TOPOISOMERASE II POISON / HEXANUCLEOTIDE / D(CGTACG)2 / 9-AMINO-DACA

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