+Search query
-Structure paper
Title | Complexes of Trypanosoma Cruzi Sterol 14Alpha-Demethylase (Cyp51) with Two Pyridine-Based Drug Candidates for Chagas Disease: Structural Basis for Pathogen-Selectivity |
---|---|
Journal, issue, pages | J. Biol. Chem., Vol. 288, Page 31602-, Year 2013 |
Publish date | Dec 14, 2012 (structure data deposition date) |
![]() | Hargrove, T.Y. / Wawrzak, Z. / Alexander, P.W. / Chaplin, J.H. / Keenan, M. / Charman, S.A. / Perez, C.J. / Waterman, M.R. / Chatelain, E. / Lepesheva, G.I. |
![]() | ![]() ![]() |
Methods | X-ray diffraction |
Resolution | 2.8 - 2.9 Å |
Structure data | ![]() PDB-3zg2: ![]() PDB-3zg3: |
Chemicals | ![]() ChemComp-HEM: ![]() ChemComp-UDO: ![]() ChemComp-HOH: ![]() ChemComp-UDD: |
Source |
|
![]() | OXIDOREDUCTASE / MONOOXYGENASE / STEROL BIOSYNTHESIS / EUKARYOTIC MEMBRANES / CYTOCHROME P450 FOLD / ENDOPLASMIC RETICULUM MEMBRANE / INHIBITOR |