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Title | Discovery of 1-[2-fluoro-4-(1H-pyrazol-1-yl)phenyl]-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one (TAK-063), a highly potent, selective, and orally active phosphodiesterase 10A (PDE10A) inhibitor. |
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Journal, issue, pages | J. Med. Chem., Vol. 57, Page 9627-9643, Year 2014 |
Publish date | Sep 1, 2014 (structure data deposition date) |
Authors | Kunitomo, J. / Yoshikawa, M. / Fushimi, M. / Kawada, A. / Quinn, J.F. / Oki, H. / Kokubo, H. / Kondo, M. / Nakashima, K. / Kamiguchi, N. ...Kunitomo, J. / Yoshikawa, M. / Fushimi, M. / Kawada, A. / Quinn, J.F. / Oki, H. / Kokubo, H. / Kondo, M. / Nakashima, K. / Kamiguchi, N. / Suzuki, K. / Kimura, H. / Taniguchi, T. |
External links | J. Med. Chem. / PubMed:25384088 |
Methods | X-ray diffraction |
Resolution | 2 - 2.68 Å |
Structure data | PDB-3wyk: PDB-3wyl: PDB-3wym: |
Chemicals | ChemComp-MG: ChemComp-ZN: ChemComp-3KG: ChemComp-HOH: ChemComp-3KB: ChemComp-3K9: |
Source |
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Keywords | HYDROLASE/HYDROLASE INHIBITOR / HYDROLASE-HYDROLASE INHIBITOR complex |