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TitleToxicity Modulation, Resistance Enzyme Evasion, and A-Site X-ray Structure of Broad-Spectrum Antibacterial Neomycin Analogs
Journal, issue, pagesAcs Chem. Biol., Vol. 9, Page 2067-2073, Year 2014
Publish dateFeb 27, 2014 (structure data deposition date)
AuthorsMaianti, J.P. / Kanazawa, H. / Dozzo, P. / Matias, R.D. / Feeney, L.A. / Armstrong, E.S. / Hildebrandt, D.J. / Kane, T.R. / Gliedt, M.J. / Goldblum, A.A. ...Maianti, J.P. / Kanazawa, H. / Dozzo, P. / Matias, R.D. / Feeney, L.A. / Armstrong, E.S. / Hildebrandt, D.J. / Kane, T.R. / Gliedt, M.J. / Goldblum, A.A. / Linsell, M.S. / Aggen, J.B. / Kondo, J. / Hanessian, S.
External linksAcs Chem. Biol. / PubMed:25019242
MethodsX-ray diffraction
Resolution2.3 Å
Structure data

PDB-3wru:
Crystal structure of the bacterial ribosomal decoding site in complex with synthetic aminoglycoside with F-HABA group
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-SJP:
(2R,3R)-4-amino-N-[(1R,2S,3R,4R,5S)-5-amino-4-[(2,6-diamino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranosyl)oxy]-3-{[3-O-(2,6-diamino-2,3,4,6-tetradeoxy-beta-L-threo-hexopyranosyl)-beta-D-ribofuranosyl]oxy}-2-hydroxycyclohexyl]-3-fluoro-2-hydroxybutanamide

ChemComp-K:
Unknown entry

ChemComp-HOH:
WATER

KeywordsRNA/antibiotic / ribosomal RNA / aminoglycoside / RNA-antibiotic complex

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