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Title | Discovery of potent Mcl-1/Bcl-xL dual inhibitors by using a hybridization strategy based on structural analysis of target proteins. |
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Journal, issue, pages | J. Med. Chem., Vol. 56, Page 9635-9645, Year 2013 |
Publish date | Sep 26, 2013 (structure data deposition date) |
![]() | Tanaka, Y. / Aikawa, K. / Nishida, G. / Homma, M. / Sogabe, S. / Igaki, S. / Hayano, Y. / Sameshima, T. / Miyahisa, I. / Kawamoto, T. ...Tanaka, Y. / Aikawa, K. / Nishida, G. / Homma, M. / Sogabe, S. / Igaki, S. / Hayano, Y. / Sameshima, T. / Miyahisa, I. / Kawamoto, T. / Tawada, M. / Imai, Y. / Inazuka, M. / Cho, N. / Imaeda, Y. / Ishikawa, T. |
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Methods | X-ray diffraction |
Resolution | 1.9 - 2.45 Å |
Structure data | ![]() PDB-3wix: ![]() PDB-3wiy: ![]() PDB-3wiz: |
Chemicals | ![]() ChemComp-LC3: ![]() ChemComp-HOH: ![]() ChemComp-LC6: ![]() ChemComp-PO4: |
Source |
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![]() | APOPTOSIS / REGULATION |