+Search query
-Structure paper
Title | Conformational restriction approach to beta-secretase (BACE1) inhibitors III: Effective investigation of the binding mode by combinational use of X-ray analysis, isothermal titration calorimetry and theoretical calculations |
---|---|
Journal, issue, pages | Bioorg. Med. Chem., Vol. 21, Page 6506-6522, Year 2013 |
Publish date | May 13, 2013 (structure data deposition date) |
![]() | Yonezawa, S. / Fujiwara, K. / Yamamoto, T. / Hattori, K. / Yamakawa, H. / Muto, C. / Hosono, M. / Tanaka, Y. / Nakano, T. / Takemoto, H. ...Yonezawa, S. / Fujiwara, K. / Yamamoto, T. / Hattori, K. / Yamakawa, H. / Muto, C. / Hosono, M. / Tanaka, Y. / Nakano, T. / Takemoto, H. / Arisawa, M. / Shuto, S. |
![]() | ![]() ![]() |
Methods | X-ray diffraction |
Resolution | 2.25 - 2.501 Å |
Structure data | ![]() PDB-3wb4: ![]() PDB-3wb5: |
Chemicals | ![]() ChemComp-GOL: ![]() ChemComp-IOD: ![]() ChemComp-0B3: ![]() ChemComp-HOH: ![]() ChemComp-DMS: ![]() ChemComp-0B4: |
Source |
|
![]() | HYDROLASE / PROTEASE 2 / ASP2 / MEMBRANE-ASSOCIATED ASPARTIC PROTEASE 2 / MEMAPSIN-2 |