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Structure paper

TitleStructure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-4-149
Journal, issue, pagesTo be Published
Publish dateFeb 27, 2013 (structure data deposition date)
AuthorsInaoka, D.K. / Iida, M. / Tabuchi, T. / Lee, N. / Hashimoto, S. / Matsuoka, S. / Kuranaga, T. / Shiba, T. / Sakamoto, K. / Suzuki, S. ...Inaoka, D.K. / Iida, M. / Tabuchi, T. / Lee, N. / Hashimoto, S. / Matsuoka, S. / Kuranaga, T. / Shiba, T. / Sakamoto, K. / Suzuki, S. / Balogun, E.O. / Nara, T. / Aoki, T. / Inoue, M. / Honma, T. / Tanaka, A. / Harada, S. / Kita, K.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution1.47 Å
Structure data

PDB-3w75:
Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-4-149
Method: X-RAY DIFFRACTION / Resolution: 1.47 Å

Chemicals

ChemComp-W75:
5-[2-(3,5-dimethoxyphenyl)ethyl]-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid

ChemComp-GOL:
GLYCEROL

ChemComp-FMN:
FLAVIN MONONUCLEOTIDE

ChemComp-NCO:
COBALT HEXAMMINE(III)

ChemComp-HOH:
WATER

Source
  • trypanosoma cruzi (eukaryote)
KeywordsOXIDOREDUCTASE/OXIDOREDUCTASE INHIBITOR / Rossmann Fold / Oxidoreductase / Dihydroorotate/orotate and fumarate/succinate binding / Cytosol / OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex

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