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-Structure paper
Title | Design and optimization of novel (2S,4S,5S)-5-amino-6-(2,2-dimethyl-5-oxo-4-phenylpiperazin-1-yl)-4-hydroxy-2-isopropylhexanamides as renin inhibitors |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 22, Page 4561-4566, Year 2012 |
Publish date | May 11, 2012 (structure data deposition date) |
Authors | Nakamura, Y. / Sugita, C. / Meguro, M. / Miyazaki, S. / Tamaki, K. / Takahashi, M. / Nagai, Y. / Nagayama, T. / Kato, M. / Suemune, H. / Nishi, T. |
External links | Bioorg. Med. Chem. Lett. / PubMed:22726934 |
Methods | X-ray diffraction |
Resolution | 2.8 - 3 Å |
Structure data | PDB-3vsw: PDB-3vsx: |
Chemicals | ChemComp-NAG: ChemComp-R31: ChemComp-R32: |
Source |
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Keywords | HYDROLASE/HYDROLASE INHIBITOR / RAS / hypertension / inhibitor / Aspartyl protease / HYDROLASE-HYDROLASE INHIBITOR complex |