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TitleDiscovery of N-[5-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)-2-methylphenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide (TAK-593), a highly potent VEGFR2 kinase inhibitor
Journal, issue, pagesBioorg. Med. Chem., Vol. 21, Page 2333-2345, Year 2013
Publish dateJan 19, 2012 (structure data deposition date)
AuthorsMiyamoto, N. / Sakai, N. / Hirayama, T. / Miwa, K. / Oguro, Y. / Oki, H. / Okada, K. / Takagi, T. / Iwata, H. / Awazu, Y. ...Miyamoto, N. / Sakai, N. / Hirayama, T. / Miwa, K. / Oguro, Y. / Oki, H. / Okada, K. / Takagi, T. / Iwata, H. / Awazu, Y. / Yamasaki, S. / Takeuchi, T. / Miki, H. / Hori, A. / Imamura, S.
External linksBioorg. Med. Chem. / PubMed:23498918
MethodsX-ray diffraction
Resolution1.52 Å
Structure data

PDB-3vo3:
Crystal Structure of the Kinase domain of Human VEGFR2 with imidazo[1,2-b]pyridazine derivative
Method: X-RAY DIFFRACTION / Resolution: 1.52 Å

Chemicals

ChemComp-0KF:
N-[3-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)phenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE/TRANSFERASE INHIBITOR / vegfr2 / kinase domain / Tyrosin-protein kinase / TRANSFERASE-TRANSFERASE INHIBITOR complex

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