+Search query
-Structure paper
Title | Discovery and preclinical profile of teneligliptin (3-[(2S,4S)-4-[4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl]pyrrolidin-2-ylcarbonyl]thiazolidine): A highly potent, selective, long-lasting and orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes |
---|---|
Journal, issue, pages | Bioorg. Med. Chem., Vol. 20, Page 5705-5719, Year 2012 |
Publish date | Oct 24, 2011 (structure data deposition date) |
Authors | Yoshida, T. / Akahoshi, F. / Sakashita, H. / Kitajima, H. / Nakamura, M. / Sonda, S. / Takeuchi, M. / Tanaka, Y. / Ueda, N. / Sekiguchi, S. ...Yoshida, T. / Akahoshi, F. / Sakashita, H. / Kitajima, H. / Nakamura, M. / Sonda, S. / Takeuchi, M. / Tanaka, Y. / Ueda, N. / Sekiguchi, S. / Ishige, T. / Shima, K. / Nabeno, M. / Abe, Y. / Anabuki, J. / Soejima, A. / Yoshida, K. / Takashina, Y. / Ishii, S. / Kiuchi, S. / Fukuda, S. / Tsutsumiuchi, R. / Kosaka, K. / Murozono, T. / Nakamaru, Y. / Utsumi, H. / Masutomi, N. / Kishida, H. / Miyaguchi, I. / Hayashi, Y. |
External links | Bioorg. Med. Chem. / PubMed:22959556 |
Methods | X-ray diffraction |
Resolution | 2.393 - 2.49 Å |
Structure data | PDB-3vjk: PDB-3vjl: |
Chemicals | ChemComp-M51: ChemComp-NAG: ChemComp-HOH: ChemComp-W94: |
Source |
|
Keywords | HYDROLASE/HYDROLASE INHIBITOR / ALPHA/BETA / BETA-PROPELLER / AMINOPEPTIDASE / SERINE PROTEASE / SIGNAL-ANCHOR / TRANSMEMBRANE / DIABETES / GLYCOPROTEIN / CELL MEMBRANE / HYDROLASE-HYDROLASE INHIBITOR complex |