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-Structure paper
Title | Activation of the p53 pathway by small-molecule-induced MDM2 and MDMX dimerization. |
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Journal, issue, pages | Proc. Natl. Acad. Sci. USA, Vol. 109, Page 11788-11793, Year 2012 |
Publish date | Sep 29, 2011 (structure data deposition date) |
![]() | Graves, B. / Thompson, T. / Xia, M. / Janson, C. / Lukacs, C. / Deo, D. / Di Lello, P. / Fry, D. / Garvie, C. / Huang, K.S. ...Graves, B. / Thompson, T. / Xia, M. / Janson, C. / Lukacs, C. / Deo, D. / Di Lello, P. / Fry, D. / Garvie, C. / Huang, K.S. / Gao, L. / Tovar, C. / Lovey, A. / Wanner, J. / Vassilev, L.T. |
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Methods | X-ray diffraction |
Resolution | 1.8 - 2.8 Å |
Structure data | ![]() PDB-3u15: ![]() PDB-3vbg: |
Chemicals | ![]() ChemComp-03M: ![]() ChemComp-SO4: ![]() ChemComp-HOH: |
Source |
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![]() | PROTEIN BINDING / cell cycle / ubiquitin ligase / MDM2 / MDMX / p53 / Ligase/ligase activator / Ligase / Ligase-ligase activator complex |