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-Structure paper
Title | Discovery of 1,2,4-Triazine Derivatives as Adenosine A(2A) Antagonists using Structure Based Drug Design |
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Journal, issue, pages | J. Med. Chem., Vol. 55, Page 1898-1903, Year 2012 |
Publish date | Dec 7, 2011 (structure data deposition date) |
![]() | Congreve, M. / Andrews, S.P. / Dore, A.S. / Hollenstein, K. / Hurrell, E. / Langmead, C.J. / Mason, J.S. / Ng, I.W. / Tehan, B. / Zhukov, A. ...Congreve, M. / Andrews, S.P. / Dore, A.S. / Hollenstein, K. / Hurrell, E. / Langmead, C.J. / Mason, J.S. / Ng, I.W. / Tehan, B. / Zhukov, A. / Weir, M. / Marshall, F.H. |
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Methods | X-ray diffraction |
Resolution | 3.273 - 3.341 Å |
Structure data | ![]() PDB-3uza: ![]() PDB-3uzc: |
Chemicals | ![]() ChemComp-T4G: ![]() ChemComp-T4E: |
Source |
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![]() | SIGNALING PROTEIN / 7TM / GPCR / G-PROTEIN / MEMBRANE PROTEIN |