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Structure paper

TitleStructures of asymmetric complexes of human neuron specific enolase with resolved substrate and product and an analogous complex with two inhibitors indicate subunit interaction and inhibitor cooperativity.
Journal, issue, pagesJ. Inorg. Biochem., Vol. 111, Page 187-194, Year 2012
Publish dateOct 26, 2011 (structure data deposition date)
AuthorsQin, J. / Chai, G. / Brewer, J.M. / Lovelace, L.L. / Lebioda, L.
External linksJ. Inorg. Biochem. / PubMed:22437160
MethodsX-ray diffraction
Resolution1.4 - 2.1 Å
Structure data

PDB-3ucc:
Asymmetric complex of human neuron specific enolase-1-PGA/PEP
Method: X-RAY DIFFRACTION / Resolution: 1.5 Å

PDB-3ucd:
Asymmetric complex of human neuron specific enolase-2-PGA/PEP
Method: X-RAY DIFFRACTION / Resolution: 1.41 Å

PDB-3uje:
Asymmetric complex of human neuron specific enolase-3-PGA/PEP
Method: X-RAY DIFFRACTION / Resolution: 1.55 Å

PDB-3ujf:
Asymmetric complex of human neuron specific enolase-4-PGA/PEP
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

PDB-3ujr:
Asymmetric complex of human neuron specific enolase-5-PGA/PEP
Method: X-RAY DIFFRACTION / Resolution: 1.4 Å

PDB-3ujs:
Asymmetric complex of human neuron specific enolase-6-PGA/PEP
Method: X-RAY DIFFRACTION / Resolution: 1.65 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-2PG:
2-PHOSPHOGLYCERIC ACID

ChemComp-TRS:
2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL / pH buffer*YM

ChemComp-HOH:
WATER

ChemComp-PEP:
PHOSPHOENOLPYRUVATE

ChemComp-XSP:
(2R)-3-oxo-2-(phosphonooxy)propanoic acid

ChemComp-0V5:
(2R)-2-(phosphonooxy)propanoic acid

Source
  • homo sapiens (human)
KeywordsLYASE

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